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2.4.1 Mechanism of cycle formation: ferroptosis triggers inflammation, and inflammation exacerbates ferroptosis The lysis of ferroptotic cells releases DAMPs, such as high-mobility group box 1 (HMGB1), ATP, and mitochondrial DNA, which activate the NOD-LRR-purine domain protein 3(NLRP3) inflammasome in macrophages, promoting the maturation and release of IL-1 and IL-18 ( It is noteworthy that ferroptosis and inflammation do not represent a unidirectional causal relationship, but rather form a bidirectional positive feedback loop